The new MerMade oligonucleotide synthesizer, 2020 model, is designed to synthesize DNA, RNA and LNA oligonucleotides in column format using standard or modified chemistries. Each of the 4 columns within this synthesizer can be assigned a different protocol to permit synthesis of oligos of different quality and yield within the same run with scales varying from 50 nmole to 5 μmol. The synthesizer is optimised for fast synthesis cycles (20mer primers in 3 hours on each column) and during the run can be paused to allow removal or addition of columns while synthesizer is in operation. Oligos up to 150 bases in length have been made with a coupling efficiency in excess of 99%, making this perfect for applications such as - dye terminator sequencing reactions - gene building - polymerase chain reactions (PCR) - hybridisation - RT-PCR - anti-sense studies - siRNA - aptamers Priced to compete with other low-through-put machines on the market, the MerMade 4 is a great choice when looking for an easy to use low cost synthesizer.