Circular RNA (circRNA) presents an opportunity to enhance pharmaceutical stability and biostability. The covalently closed structures of circRNA are resistant to RNA exonucleases and eliminate the need for expensive capping technology.
Ensure translation accuracy in circular RNA synthesis by in vitro transcription (IVT) with RNase R (Epicentre RNase R). RNase R is a magnesium-dependent 3′ → 5′ exoribonuclease that digests linear RNAs after circularisation, enhancing protein production.
LGC Biosearch Technologies™ manufactures RNase R (Epicentre RNase R) in our ISO-13485 accredited manufacturing facilities in Middleton, WI USA with convenient international fulfillment through our global operations.
Order RNase RIn addition to RNase R, we offer a wide selection of specialised enzymes for circular RNA synthesis.
Many of our enzymes are cited in publications as sourced from Lucigen and Epicentre, which are now part of Biosearch Technologies.
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Backed by 25 years of expertise in enzyme development and production, we also offer custom formulations of in vitro transcription enzymes (IVT enzymes). Like all of our enzymes, we manufacture custom enzymes in our ISO-13485 accredited facilities. We offer customisations to support you from early method development to large-scale production.
Popular enzyme customisations for circular RNA synthesis:
In addition to customising our enzymes to meet your requirements, you can also partner with us to manufacture your proprietary IVT enzyme constructs in our ISO-13485 accredited facilities.
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A circular RNA (circRNA) vaccine that encodes the trimeric RBD antigens of SARS-CoV-2 spike provides protection and memory boosting against SARSCoV-2.
This study provided the first evidence of viral circRNAs that were expressed at key steps of the Marek’s disease virus lifecycle using genome-wide analyses of circRNAs.
Human cytomegalovirus (HCMV) infects a large portion of the human population globally. Several HCMV-derived noncoding RNAs are involved in the regulation of viral gene expression and the virus life cycle.
Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by in vitro transcription and ligation.
This study provided a general platform for efficient production of circRNAs, demonstrating the potential of circRNAs as the new generation of mRNA therapy.
Tell us more about your project using the form below and our technical support team will help you find the right specialised enzyme for your project.
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