New Site Launched: Looking for oligos? Visit our new oligo and Stellaris dedicated platform at
oligos.biosearchtech.com
Propyne dC (DBF) Amidite
You are currently seeing list prices, to see your prices please log in
Propyne dC (DBF) Amidite
Phosphoramidite used to incorporate a C-5 propyne modified dC either internally or at the 5' end of an oligonucleotide.
Key features
Show- Enhances base pairing.
- Confers duplex stability and melting temperatures are raised by 2.8° per substitution.
- Confers nuclease resistance and binding affinity of antisense oligos.
Added to basket
Product information
Substitution of C-5 propynyl-dC (pdC) for dC and C-5 propynyl-dU (pdU) for dT are effective strategies to enhance base pairing. Duplex stability and melting temperatures are raised by 2.8° or 1.7° per substitution of pdC or pdU respectively. Such Tm modification is used in Turbo Taqman probes for example. C5-propyne pyrimidine modifications are sometimes added to increase nuclease resistance and binding affinity of antisense oligos.
Product usage:
- Image of cleaved and deprotected structure:
Access support
Need some support with placing an order, setting up an account, or finding the right protocol?
Contact us