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5'-DMT-dA(Bz)-3'-Q Linker-CPG uses a hydroquinone-0,0'-diacetic acid group (Q-linker) to attach the nucleoside to the CPG. Q Linker CPG supports are advantageous because they require a very short amount of time for cleavage (they can be cleaved in 2 minutes at room temperature) making them ideal for base sensitive oligonucleotides or dye labeled oligos.
Properties:
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Chemical Name:
5'-DMT-dA(Bz)-3'-Q Linker-CPG; 1000 Å
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Appearance:
White Powder
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Extinction Coefficient at 260 nm:
15200
Spectral properties measured in water, for the cleaved and deprotected nucleoside.
Product usage:
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Synthesis conditions:
Synthesis can be performed on these supports according to standard procedures with deprotection and cleavage modifications noted.
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Cleavage conditions:
Cleavage can be carried out in 2 minutes at room temperature using concentrated NH4OH.
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Deprotection conditions:
If fast deprotecting amidites are used, deprotection can be carried out using concentrated NH4OH for 1 hour @ 60 °C.
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The mass this product adds after conjugation and work-up (the additional mass seen by mass spectrometry) is:
313.2
Image of cleaved and deprotected structure:
Storage and handling:
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Shipping conditions:
Ambient
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Storage conditions:
+2 to +8 °C
